The Golden Iris Virus maintains its stranglehold on Gotham City, with its manic victims now descending upon a car dealership with explosive results for the Bat-Family. Elsewhen, in the Gotham City of the 1800s, Runaway finds themselves in a shaky alliance with Vandal Savage, who holds clues to the origins, and possibly the antidote, to the strange illness plaguing the city across centuries.